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KMID : 0364820190550030268
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Korean Journal of Microbiology
2019 Volume.55 No. 3 p.268 ~ p.273
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Comparison of gut microbial diversity of breast-fed and formula-fed infants
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Kim Kyeong-Soon
Shin Jung
Sim Ji-Soo
Yeon Su-Ji
Lee Pyeong-An
Chung Moon-Gyu
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Abstract
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The intestinal microbiomes vary according to the factors such environment, age and diet. The purpose of this study was to compare the gut microbial diversity between Korean infants receiving breast-fed milk and formula-fed milk. We analyzed microbial communities in stool samples collected from 80 Korean infants using next generation sequencing. Phylum level analysis revealed that microbial communities in both breast-fed infants group (BIG) was dominated by Actinobacteria (74.22 ± 3.48%). Interestingly, the phylum Actinobacteria was dominant in formula-fed infants group A (FIG-A) at 73.46 ± 4.12%, but the proportions of phylum Actinobacteria were lower in formulafed infants group B and C (FIG-B and FIG-C) at 66.52 ± 5.80% and 68.88 ± 4.33%. The most abundant genus in the BIG, FIG-A, FIG-B, and FIG-C was Bifidobacterium, comprising 73.09 ± 2.31%, 72.25 ± 4.93%, 63.81 ± 6.05%, and 67.42 ± 5.36% of the total bacteria. Furthermore, the dominant bifidobacterial species detected in BIG and FIG-A was Bifidobacterium longum at 68.77 ± 6.07% and 66.85 ± 4.99% of the total bacteria.
In contrast, the proportions of B. longum of FIG-B and FIG-C were 58.94 ± 6.20% and 61.86 ± 5.31% of the total bacteria.
FIG-A showed a community similar to BIG, which may be due to the inclusion of galactooligosaccharide, galactosyllactose, synergy-oligosaccharide, bifidooligo and improvement material of gut microbiota contained in formula-milk. We conclude that 5-Bifidus factor contained in milk powder promotes the growth of Bifidobacterium genus in the intestines.
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KEYWORD
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Bifidobacterium longum, 5-Bifidus factor, breast-fed, formula-fed, next generation sequencing
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